I am a postdoctoral researcher in Prof. Paola Arlotta's laboratory at Harvard University,
where I study the molecular mechanisms that govern axonal myelination in the cerebral cortex.
My work focuses on how neurons and oligodendrocytes communicate during development to generate
distinct myelin profiles across cortical layers. I completed my PhD at KU Leuven, where I
investigated how CYFIP1 — a gene associated with autism spectrum disorder (ASD) and
schizophrenia — regulates axonal development, brain connectivity, and white matter
architecture, contributing to the connectivity defects observed in patients.
Looking ahead, I aim to identify the molecular signals that guide myelination along
individual axons and determine how disruptions in this process contribute to
neurodevelopmental disorders such as ASD and schizophrenia.
Publications
2026
Molecular cues from distinct neuron classes drive differential myelination in the neocortex
Domínguez-Iturza N*, Jokhi V*, Kim K*, Shetty AS, Di Bella DJ, Pereira Luppi M, Yuan W, Abbate C, Oyler-Castrillo P, Oliver NA, Venkat V, Jin X, Simmons S, Levin JZ, Brown JR, Arlotta P
Neurotrophin receptor p75NTR mediates Huntington's disease–associated synaptic and memory dysfunction
Brito V, Giralt A, Enriquez-Barreto L, Puigdellívol M, Suelves N, Zamora-Moratalla A, Ballesteros JJ, Martín ED, Dominguez-Iturza N, Morales M, Alberch J, Ginés S
Journal of Clinical Investigation124(10):4411–4428, 2014